プレクリニカル・イメージングシステム データギャラリー

[No.02] 123Iβ-CIT　Mouse Brain

使用装置 SPECT
解説 Study included 6 Mice MPTP (neurotoxin) was given to test subjects to deplete dopamine transporters in the striatum 3 controls (250-600microCi) Animal Protocol: 123I ·-CIT injected into tail vein Imaging Started one hour after injection 1.0 mm Pinhole aperture, 64 projections, 1min./proj. Three fiduciary markers were used Significant results: MPTP treated mice showed far less striatal uptake than controls, demonstrating the dopamine transporters in the striata depleted by MPTP.

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123β-CIT Mouse Brain

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Dopamine transporters are important component of brain function. These images of two separate mice showing brain injected with 123I tagged B-CIT which binds to the dopamine transporters. Dopamine transporter density in the brain is shown in these images. Normal uptake of this agent is in the eyes, also dissociated iodine is taken up in the thyroid (control). Gendelman is developing animal models for study of Parkinson’s Disease. By applying MPTP which depletes the dopamine transporters his group mimics Parkinson’s. Image of treated mouse shows lower density of dopamine transporters in the brain as compared to the normal uptake in the eyes. This type of animal model in combination with non-invasive imaging can be used to develop treatment and prevention of Parkinson’s Disease.

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